About RNA Shield™
RNA is susceptible to degradation by exposure to ubiquitous ribonucleases, elevated temperatures, pH extremes, and other harsh conditions. The stabilization of intact RNA is a key factor that determines the quality and consistency of downstream analyses. Improper sample collection and storage can dramatically and irreversibly compromise the integrity of RNA.
RNA Shield™ instantly lyses cells, ensures RNA stability and preserves expression profiles during transport or long-term storage at ambient temperature without the need for cold storage or specialized equipment. RNA Shield™ effectively inactivates RNases and infectious agents. Simply add a sample to RNA Shield™ and store/transport for later processing of high-quality RNA. Samples in RNA Shield™ can be added directly to most of Zymo Research's RNA purification kits, unlike other reagents, which require complicated and time-consuming removal steps.
* RNA Shield™ stabilizes both RNA and DNA at ambient temperature.
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Cellular RNA is effectively stabilized in RNA Shield™ at ambient temperature. RNA was purified directly from samples in RNA Shield™ using the RNA Shield™ Purification Kit. |
Herpes Simplex Virus is effectively inactivated by RNA Shield™. HSV-1 (dark gray) & HSV-2 (light gray) inactivation following a 5 minute incubation in the RNA Shield™ reagent (H. Oh, F. Diaz and D. Knipe; Harvard Medical School). |
RNA is purified directly from RNA Shield™ without the need for reagent removal. Cellular RNA was purified from samples stabilized in RNA Shield™ using TRIzol® together with the Direct-zol™ RNA MiniPrep. RNAlater® did not facilitate direct purification using this method. |
