Zymo Research, a specialist in the field of epigenetics for nearly a decade, has entered into a new collaboration with BaseClear to offer a unique Epigenetic Biomarker Discovery Service in Europe.

Orange, California, USA and Leiden, The Netherlands, Oct. 19th , 2011 — In collaboration with Zymo Research, BaseClear is now able to offer methylome analysis, which yields the DNA methylation profile of an entire genome (at a genomic scale). BaseClear customers will already be familiar with Zymo Research through the laboratory products (reagents) that constitute part of BaseClear’s lab product portfolio. Last year, Zymo Research developed a new method which combines next generation sequencing and bioinformatics with their well-established bisulfite technologies for comprehensive DNA methylation analysis (EpiQuest™). With the EpiQuest™ service Zymo Research and BaseClear are the first to offer a complete and extensive DNA methylation service based on next generation technology to the market. European researchers can now make use of this service via BaseClear. Customers can opt for a basic variant that provides next generation sequencing data aligned with a reference genome (through three UCSC genome browser tracks), and a full service variant, which includes comprehensive bioinformatics analysis. Advantages of this new service include: precise quantitation, single nucleotide resolution, low DNA input, applicable to a broad range of sample sources, consolidated data delivery, and more. Customized services can, of course, always be provided upon request. Determining DNA methylation patterns on a genomic scale and discovering new epigenetic biomarkers are now feasible. Dr. L. Jia, Zymo Research says: “The services should have a profound impact on candidate biomarker discovery and how we diagnose disease. Further, these technologies should make available the creation of companion diagnostics that coincide with therapeutic development. We are excited with this collaboration with which we hope to expand the epigenetics portfolio enabling us to better serve customers in Europe" Drs. B. Reichert, BaseClear adds: “The extension of our services with the EpiQuest service fits perfectly in our strategy to build a complete package of high quality genome analysis service. We are also excited about strengthening of our collaboration with Zymo Research and expect that joining forces in this fast developing field of research will allow us to add more services that would benefit to our customers in the near future.”

About ZYMO RESEARCH CORPORATION Zymo Research, a private company based in Orange, California, and founded in 1994, has been proudly serving the scientific community by providing proven, trusted, and state-of-the-art DNA and RNA research technologies at affordable prices. The company’s philosophy is to provide the highest quality products in the industry while ensuring they are both simple to use and robust in their performance. Although historically recognized for its innovative DNA and RNA purification technologies, Zymo Research has recently received much attention for its rapidly expanding epigenetics portfolio of products. Branding itself “The Epigenetics Company”, it is Zymo Research’s objective to develop and provide the most comprehensive set of research tools for DNA methylation analysis and epigenetics research available today.

About BASECLEAR BaseClear B.V., a private company based in Leiden, The Netherlands, was founded in 1993 as a service laboratory dedicated to deliver high quality DNA based services to researchers in the life sciences. At date the company offers a broad range of services ranging from single read DNA sequencing, Whole genome sequencing using NextGeneration platforms, synthetic DNA biology and services for forensics and quality control purposes and a whole package of supporting technologies. BaseClear strives to deliver services at an exceptional high quality level and with a strong focus on customer satisfaction, which is guaranteed through our ISO 17025 quality system and further through Illumina CSpro and Nimblegen CSpro certifications. ‘BaseClear, for 100% DNA results.’ For more information, contact: services@zymoresearch.com www.zymoresearch.com