Credit Orders: Currently, online ordering is not available via credit card (PO can still be processed).
Please call 888-882-9682 for assistance. We apologize for the inconvenience; use code NEWWEB10 for a 10% discount.

DNA/RNA Shield™

Preserves genetic integrity and expression profiles of samples (cells, tissues, blood, plasma, serum, saliva, urine, feces etc.) at ambient temperatures.
DNA and RNA can be isolated directly without precipitation or reagent removal (compatible with most DNA and RNA purification kits).
Inactivates infectious agents (virus).

Product Size Catalog # Price Qty
DNA/RNA Shield™ 50 ml R1100-50
DNA/RNA Shield™ 250 ml R1100-250
DNA/RNA Shield™ (2X concentrate) 25 ml R1200-25
DNA/RNA Shield™ (2X concentrate) 125 ml R1200-125

About DNA/RNA Shield™

Contact us with any custom needs at

Product(s) Specifications

  • RNA stable at room temperature for 1 month
  • DNA stable at room temperature for 2 years
  • Ready for nucleic-acid extraction using:

Purification Of




Blood Samples

Quick-DNA™ (Plus)

Quick-RNA™ Whole Blood

ZR-Duet™ DNA/RNA (Plus)

Microbiomic Samples




Viral Samples

Quick-DNA™ Viral

Quick-RNA™ Viral


Biological Fluids, Cells, Insect, Tissue

Quick-DNA™ (Plus)

Quick-RNA™ (Plus)

ZR-Duet™ DNA/RNA (Plus)

DNA/RNA Shield™ ensures nucleic acid stability during sample storage/transport at ambient temperatures. There is no need for refrigeration or specialized equipment. DNA/RNA Shield™ effectively lyses cells and inactivates nucleases and infectious agents (virus), and it is compatible with various collection and storage devices (vacutainers, swabs, nasal, buccal, fecal etc.).

RNA Stabilization

Nucleic Acid Purification

Cellular RNA is effectively stabilized in DNA/RNA Shield™ at ambient temperature. RNA was purified from cells (HCT 116) stored in DNA/RNA Shield™ at the designated times (days).
High quality DNA and RNA is efficiently purified from blood stored in DNA/RNA Shield™ using the Quick-gDNA™ and Quick-RNA™ Kits from Zymo Research, respectively. High molecular weight DNA was intact with no apparent degradation. Also, RNA was high quality, DNA-free, and included small RNAs when purified from DNA/RNA Shield™. This was not the case using another reagent/kit from Supplier B.

Virus Inactivation

Influenza virus is effectively inactivated by DNA/RNA Shield™. Influenza A virus was treated with four volumes of DNA/RNA Shield™ or mock treated for 5 minutes. Titer was subsequently determined by plaque assay. (D. Poole and A. Mehle, University of Wisconsin-Madison)

Ebola virus is effectively inactivated by DNA/RNA Shield™.  Ebola virus (Kikwit) was treated with two volumes of DNA/RNA Shield™ or PBS for 5 minutes at ambient temperature.  Titer was subsequently determined by plaque assay.  (L. Avena and A. Griffiths, Texas Biomedical Research Institute)

Herpes Simplex Virus is effectively inactivated by DNA/RNA Shield™. HSV-1 (dark gray) & HSV-2 (light gray) inactivation following a 5 minute incubation in the DNA/RNA Shield™. (H. Oh, F. Diaz and D. Knipe; Harvard Medical School)

Submit your Citation
GETTING PUBLISHED? Take some time to celebrate and enjoy the little things in life!

Getting published is not only hard work, it takes enormous amounts of time and dedication. Zymo Research would like to celebrate your achievement! Let us know when you have cited any of our products in your recent publication and get a $20 Amazon gift code.

Click here to submit your review of the DNA/RNA Shield™.

Call Us


We're here Mon - Fri 8am - 5pm PST

Send an Email

We'll reply within 24 hours