Reduced Representation Hydroxymethylation Profiling (RRHP)
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This service is for genome-wide profiling of 5-hydroxymethylcytosine in DNA at single-nucleotide resolution. RRHP also allows strand-specific determination of the location of the 5-hmC modification as well as quantification of 5-hmC levels. Data from RRHP is easily integrated with DNA methylation data from Methyl-MiniSeq™ (previous page), allowing for direct comparison of DNA methylation and hydroxymethylation in the same sample. Omission of chemical conversion processes allows for both low DNA input as well as straightforward SNP detection.
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