The advent of Next-Generation sequencing has supercharged our ability to explore both human and environmental microbial ecosystems using targeted sequencing approaches such as 16S rRNA and shotgun sequencing approaches. This has led to an explosion in the field of microbiomics. However, proper standards and quality control measures have lagged behind. The microbiomics community has expressed a need to standardize methods to improve the reproducibility and quality of the data being generated. As such, Zymo Research developed the first commercially available Microbiomics Standards for the development, evaluation, calibration, and validation of complex microbiomics workflows encompassing sample collection, sample preparation, and analyses. Zymo Research is also the first supplier to validate every step of the process using Microbial Community Standards to ensure our tools and services are accurate. The ZymoBIOMICS™ portfolio has been developed as a comprehensive solution for microbiomics and metagenomics from collection to analyses.
Zymo Research provides (1) sample collection tools that can reliably provide a molecular snapshot at the time of collection by stabilizing the nucleic acids at ambient temperature and rendering the sample noninfectious for safe transport; (2) purification methodologies that take into consideration the biases associated with differential lysis efficiency of the organism being processed (e.g. Gram-positive and negative bacteria, fungus, viruses, and associated spores); (3) analytical pipelines that reduce bias due to library preparation methods, PCR, and bioinformatics (e.g. GC content, log difference organism abundances, detection limit, and ability to distinguish closely related organisms).
At Zymo Research, we have made it our goal to eliminate bias across the entire microbiomic workflow. Our new product line, ZymoBIOMICS™, is a complete workflow, from collection to analysis, which offers streamlined collection, purification, and the first microbial community standards.
Preserving RNA integrity prior to RNA isolation remains one of the biggest challenges to the success of many RNA applications, and DNA/RNA Shield™ from Zymo Research provides the solution by stabilizing RNA (and DNA) during sample collection, storage, and purification – all while completely inactivating RNases and potentially infectious agents in samples. (Learn More)