EpiBeat - The Latest in Epigenetics News
Non-coding RNA Expression is Synergistically modulated by Various Types of Epigenetic Modifications
It is well known that most of the mammalian genome is transcribed, producing large amounts of non-coding RNAs (ncRNAs). The two main types of ncRNA are micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs). MiRNAs are a recently discovered... [Read more on EpiBeat]
DNA Methylation in the Placenta: accelerated aging in pregnancy complications
The placenta is a unique organ as it is an extra-embryonic tissue primarily regulated by the fetal genome and shared between mother and fetus. However, it is a transient organ that is only needed throughout pregnancy and gestation... [Read more on EpiBeat]
Activated protein C ameliorates diabetic nephropathy (kidney disease) by epigenetically inhibiting the enzyme p66Shc
Activated protein C (aPC) is a serine protease that is lost during diabetes. Previously it has been shown that aPC protects against diabetic nephropathy (dNP)1, a progressive kidney disease caused by damage to the capillaries.  aPC’s... [Read more on EpiBeat]
MicroRNA expression is regulated by DNA methylation: a complex cascade of gene regulation events
MicroRNAs (miRNAs) are non-coding RNAs, roughly 22 nucleotides in size that are central and negative regulators of gene expression. They exert their functions through base-pairing with the 3’UTR of mRNAs   and block expression... [Read more on EpiBeat]
A Better Model System for Ovarian Cancer: Patient-derived tumor xenografts (PDXs) are suitable for epigenetic methylome-based cancer research
Ovarian cancer is the most lethal gynecologic malignancy. After epigenomic analysis of patient tumors, aberrant DNA methylation patterns are universally observed in the most abundant histological subtype of ovarian cancer, high-grade... [Read more on EpiBeat]
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