Zymo Research's OneStep qMethyl™ technology offers an enticing alternative to long and tedious bisulfite sequencing. Through an optimized workflow that literally involves one step, researchers are able to use restriction enzyme digestion and qPCR to determine methylation percentage of many samples or multiple loci in just 4 hours. The advantages and applications of the OneStep qMethyl kit were recently featured in this week's EpiGenie.