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DNA Methylation

DNA Methylation Overview

DNA Methylation

DNA can be modified by methylation of cytosine bases, particularly cytosines preceding guanines (CpG dinucleotides), by enzymes called DNA methyltransferases. This epigenetic modification generally functions to repress gene expression and is important for the regulation of cellular differentiation and development. DNA methylation can also serve as an epigenetic biomarker for many human diseases.

Bisulfite conversion, also known as bisulfite treatment, is used to deaminate non-methylated cytosine to produce uracil in DNA. Methylated cytosines (5-methylcytosines) are protected from the conversion to uracil, allowing the use of sequencing to determine their locations at single-nucleotide resolution. Bisulfite is considered the "gold standard" for downstream applications to assess DNA methylation status. The EZ DNA Methylation products by Zymo Research are the most cited and trusted products in the industry for investigating DNA methylation. We also offers many other products to facilitate DNA methylation experiments, such as methylation-sensitive enzymatic approaches to provide region-specific resolution of methylation status, methylated DNA standards, DNA methyltransferase enzymes, antibodies, and products and services for genome-wide DNA methylation analyses.

DNA Methylation Technologies

DNA Methyltransferases

Zymo Research offers several highly active DNA methyltransferase enzymes for use in epigenetics research.  (Learn More)

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Rapid, high-throughput adaptable assay for specific and accurate detection and quantification of global 5-methylcytosine levels in DNA.  (Learn More)

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5-mC Antibodies & Immunoprecipitation

Specifically and reproducibly detect and enrich methylated DNA with Zymo Research’s highly specific anti-5-methylcytosine antibody.  (Learn More)

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Region-Specific DNA Methylation Analysis

Single step, real-time PCR procedures for bisulfite-free determination of region-specific DNA methylation status.  (Learn More)

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Global 5-mC Quantification

The extent of DNA methylation can be accurately determined on a global scale by mass spectrometry or sensitive chromatography methods following digestion of the DNA to individual nucleoside or nucleotide components.  (Learn More)

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