Zymo Research Corporation—The Epigenetics Company—continues to expand its range of tools and services for scientists working in the field of epigenetics with the release of its new EZ RNA Methylation™ Kit. This first-of-its-kind kit is specifically designed and optimized for bisulfite conversion of RNA for 5-methylcytosine detection. Zymo Research now makes it easy for scientists to investigate RNA methylation, in addition to many other epigenetic modifications, with their comprehensive suite of products and services for epigenetic analysis, including genome-wide platforms for profiling DNA methylation and hydroxymethylation, and other services such as ChIP-Seq and RNA-Seq.

 

The importance of RNA modification, particularly RNA methylation, in the regulation of biological processes is another quickly expanding frontier of epigenetics-based research. Until recently, the majority of epigenetic research has focused on modifications to DNA and its associated proteins. But RNA is also known to be extensively modified, and in fact, over 100 different RNA modifications have been reported. With the EZ RNA Methylation™ Kit, Zymo Research has opened the door for scientists also to look more closely at the modifications of RNA. Because RNA molecules perform many different functions in cells, ranging from protein translation to gene silencing and enzymatic activity, the potential for biologically relevant changes to RNA is significant. This information may be critical to expanding the mechanistic understanding of epigenetics in biology and in human diseases, such as cancer and dementia, as well as the aging process itself.

 

While sequencing the human genome was a significant step in our understanding of biology, new advancements in technology are making sequencing of human genomes now almost routine. Presently, in the post-genomic era, it is becoming increasingly clear that genetics alone cannot explain many questions. According to Seth Ruga, product manager at Zymo Research, “The study of epigenetics, including RNA methylation, is helping to clarify how the genome is expressed and how both genetic and environmental factors can contribute to who we are and what we are likely to become. Epigenetics will undoubtedly provide insight into many aspects of human health, development, disease, and aging (just to name just a few) and how experiences and behavior may impact not only ourselves, but also our progeny…” RNA methylation is only one more piece in the complex puzzle of epigenetics and the intricate events that comprise and control gene regulation.

 

For more information about epigenetic products and services, please click here or contact us at info@zymoresearch.com 

Zymo Research Corporation, The Epigenetics Company, announces the launch of their services for genetic, epigenetic, and expression analysis.  Zymo Research has developed products and technologies for epigenetics research for over a decade, and two years ago introduced unique methods for genome-wide analysis of DNA methylation.  Since then, Zymo Research has continued to expand their epigenetic analysis capabilities and is now the most established and complete provider of epigenetic services.  Services are available for investigating DNA methylation (5-mC) and hydroxymethylation (5-hmC), as well as targeted DNA methylation analysis of single or multiple genetic loci.  Multiple service options are available to the researcher; each offering varying degrees of genome coverage, so customers can choose the analysis best suited for their needs.  Zymo Research’s epigenetic services make genome-wide analyses affordable for nearly every budget.  No experience with sequencing or bioinformatics technologies is required – simply submit the samples and receive high quality, easy-to-interpret publication-ready data and figures.

 

There are many unique benefits to using the services offered by Zymo Research, including: the most highly-cited chemistries for bisulfite treatment of DNA for 5-mC analysis, novel library prep workflows for ultra-low DNA inputs, and custom-designed bioinformatics pipelines to ensure seamless data handling, analysis, and delivery.  Additionally, the scientists at Zymo Research have recently developed a novel technique to determine DNA hydroxymethylation levels on a genome-wide scale called Reduced Representation Hydroxymethylation Profiling (RRHP).  RRHP, a service offered exclusively by Zymo Research, is the only method available for reliable single base-pair resolution and strand-specific profiling of 5-hmC modifications in DNA.  Additional services are also available for genetic, epigenetic, and expression analysis, including 5-hmC CapSeq, ChIP-Seq, nucleosome position mapping, RNA-Seq, targeted DNA sequencing, large and small genome sequencing, mitochondrial DNA sequencing, and analysis of DNA modifications by mass spectrometry.  These services can be combined and customized to meet the needs of the researcher depending on the requirements of any particular study.

 

According to Dr. Marc Van Eden, V.P. of Business Development at Zymo Research, “High throughput Next-Gen sequencing is no longer only reserved for those labs with seemingly unlimited resources.  Now, with the service platforms and bioinformatics technologies from Zymo Research, every laboratory will have access to genome-wide genetic and epigenetic analysis.  This will mark the beginning of a new era in epi-biomarker discovery and validation that will aid in the diagnostics and prognostics of human diseases, and facilitate personalized medicine and companion diagnostics to optimize the efficiency of individualized drug treatment.  Also, we may begin to ask how things like the environment and our diet affect who we are and who we will likely become.”  Dr. Van Eden continues, “The bioinformatics experts at Zymo Research take care of the number crunching and bioinformatics analysis so the customer doesn’t have to.  In addition to sending customers raw data, we also send results in easy-to-digest customizable reports.  Now genome-wide analysis and bioinformatics couldn’t be easier.”

 

 

For more information about the epigenetic services, or to inquire, please click here or contact us at services@zymoresearch.com.

Following the publication of the sequence of the human genome in 2001, and more recently the ENCODE Project in 2012, it has become clear that genes and chromatin are far more complicated than previously anticipated. DNA once believed to be "junk" has been found to code for specific non-coding transcripts and to contain important regulatory elements. It is now apparent that investigating one or a few genes is no longer sufficient to answer the questions currently posed by researchers in the fields of molecular biology, genetics, and systems biology.   

Zymo Research makes these analyses available to every researcher with its repertoire of genome-wide services! All Next-Gen Epigenetic Services feature state-of-the-art sample prep technologies, workflows, cutting-edge bioinformatics, and all are offered at competitive pricing. With our services, you don't have to be a bioinformatics guru; instead our bioinformatics specialists will provide you the data as a comprehensive report that can be customized to fit your needs. Since we develop most of the technologies used for our services, our bioinformatics specialists are always available to answer your questions and assist you every step of the way.

The scientists at Zymo Research have been developing industry leading epigenetic technologies and workflows for more than a decade, and they remain committed to pioneering new research tools and services to meet the future challenges of the rapidly growing field of epigenetics.

We are proud to introduce Zymo Research Corporation’s brand-new Epigenetic Tools, a free online resource for epigenetics researchers. Try Bisulfite Primer Seeker for the design of robust, unbiased post-bisulfite PCR primers from your target sequence. Users can also calculate methylation percentage by using qMethyl Calculator in conjunction with our OneStep qMethyl™ kit. As we continue to develop more tools, we will add them to the website in order to continue to simplify your epigenetics research and share our wealth of knowledge and experience in this area.