Zymo Research Corporation, The Epigenetics Company, announces the launch of their services for genetic, epigenetic, and expression analysis.  Zymo Research has developed products and technologies for epigenetics research for over a decade, and two years ago introduced unique methods for genome-wide analysis of DNA methylation.  Since then, Zymo Research has continued to expand their epigenetic analysis capabilities and is now the most established and complete provider of epigenetic services.  Services are available for investigating DNA methylation (5-mC) and hydroxymethylation (5-hmC), as well as targeted DNA methylation analysis of single or multiple genetic loci.  Multiple service options are available to the researcher; each offering varying degrees of genome coverage, so customers can choose the analysis best suited for their needs.  Zymo Research’s epigenetic services make genome-wide analyses affordable for nearly every budget.  No experience with sequencing or bioinformatics technologies is required – simply submit the samples and receive high quality, easy-to-interpret publication-ready data and figures.


There are many unique benefits to using the services offered by Zymo Research, including: the most highly-cited chemistries for bisulfite treatment of DNA for 5-mC analysis, novel library prep workflows for ultra-low DNA inputs, and custom-designed bioinformatics pipelines to ensure seamless data handling, analysis, and delivery.  Additionally, the scientists at Zymo Research have recently developed a novel technique to determine DNA hydroxymethylation levels on a genome-wide scale called Reduced Representation Hydroxymethylation Profiling (RRHP).  RRHP, a service offered exclusively by Zymo Research, is the only method available for reliable single base-pair resolution and strand-specific profiling of 5-hmC modifications in DNA.  Additional services are also available for genetic, epigenetic, and expression analysis, including 5-hmC CapSeq, ChIP-Seq, nucleosome position mapping, RNA-Seq, targeted DNA sequencing, large and small genome sequencing, mitochondrial DNA sequencing, and analysis of DNA modifications by mass spectrometry.  These services can be combined and customized to meet the needs of the researcher depending on the requirements of any particular study.


According to Dr. Marc Van Eden, V.P. of Business Development at Zymo Research, “High throughput Next-Gen sequencing is no longer only reserved for those labs with seemingly unlimited resources.  Now, with the service platforms and bioinformatics technologies from Zymo Research, every laboratory will have access to genome-wide genetic and epigenetic analysis.  This will mark the beginning of a new era in epi-biomarker discovery and validation that will aid in the diagnostics and prognostics of human diseases, and facilitate personalized medicine and companion diagnostics to optimize the efficiency of individualized drug treatment.  Also, we may begin to ask how things like the environment and our diet affect who we are and who we will likely become.”  Dr. Van Eden continues, “The bioinformatics experts at Zymo Research take care of the number crunching and bioinformatics analysis so the customer doesn’t have to.  In addition to sending customers raw data, we also send results in easy-to-digest customizable reports.  Now genome-wide analysis and bioinformatics couldn’t be easier.”



For more information about the epigenetic services, or to inquire, please click here or contact us at services@zymoresearch.com.

Following the publication of the sequence of the human genome in 2001, and more recently the ENCODE Project in 2012, it has become clear that genes and chromatin are far more complicated than previously anticipated. DNA once believed to be "junk" has been found to code for specific non-coding transcripts and to contain important regulatory elements. It is now apparent that investigating one or a few genes is no longer sufficient to answer the questions currently posed by researchers in the fields of molecular biology, genetics, and systems biology.   

Zymo Research makes these analyses available to every researcher with its repertoire of genome-wide services! All Next-Gen Epigenetic Services feature state-of-the-art sample prep technologies, workflows, cutting-edge bioinformatics, and all are offered at competitive pricing. With our services, you don't have to be a bioinformatics guru; instead our bioinformatics specialists will provide you the data as a comprehensive report that can be customized to fit your needs. Since we develop most of the technologies used for our services, our bioinformatics specialists are always available to answer your questions and assist you every step of the way.

The scientists at Zymo Research have been developing industry leading epigenetic technologies and workflows for more than a decade, and they remain committed to pioneering new research tools and services to meet the future challenges of the rapidly growing field of epigenetics.

We are proud to introduce Zymo Research Corporation’s brand-new Epigenetic Tools, a free online resource for epigenetics researchers. Try Bisulfite Primer Seeker for the design of robust, unbiased post-bisulfite PCR primers from your target sequence. Users can also calculate methylation percentage by using qMethyl Calculator in conjunction with our OneStep qMethyl™ kit. As we continue to develop more tools, we will add them to the website in order to continue to simplify your epigenetics research and share our wealth of knowledge and experience in this area.

Zymo Research, a specialist in the field of epigenetics for nearly a decade, has entered into a new collaboration with BaseClear to offer a unique Epigenetic Biomarker Discovery Service in Europe.

Orange, California, USA and Leiden, The Netherlands, Oct. 19th , 2011 — In collaboration with Zymo Research, BaseClear is now able to offer methylome analysis, which yields the DNA methylation profile of an entire genome (at a genomic scale). BaseClear customers will already be familiar with Zymo Research through the laboratory products (reagents) that constitute part of BaseClear’s lab product portfolio. Last year, Zymo Research developed a new method which combines next generation sequencing and bioinformatics with their well-established bisulfite technologies for comprehensive DNA methylation analysis (EpiQuest™). With the EpiQuest™ service Zymo Research and BaseClear are the first to offer a complete and extensive DNA methylation service based on next generation technology to the market. European researchers can now make use of this service via BaseClear. Customers can opt for a basic variant that provides next generation sequencing data aligned with a reference genome (through three UCSC genome browser tracks), and a full service variant, which includes comprehensive bioinformatics analysis. Advantages of this new service include: precise quantitation, single nucleotide resolution, low DNA input, applicable to a broad range of sample sources, consolidated data delivery, and more. Customized services can, of course, always be provided upon request. Determining DNA methylation patterns on a genomic scale and discovering new epigenetic biomarkers are now feasible. Dr. L. Jia, Zymo Research says: “The services should have a profound impact on candidate biomarker discovery and how we diagnose disease. Further, these technologies should make available the creation of companion diagnostics that coincide with therapeutic development. We are excited with this collaboration with which we hope to expand the epigenetics portfolio enabling us to better serve customers in Europe" Drs. B. Reichert, BaseClear adds: “The extension of our services with the EpiQuest service fits perfectly in our strategy to build a complete package of high quality genome analysis service. We are also excited about strengthening of our collaboration with Zymo Research and expect that joining forces in this fast developing field of research will allow us to add more services that would benefit to our customers in the near future.”

About ZYMO RESEARCH CORPORATION Zymo Research, a private company based in Orange, California, and founded in 1994, has been proudly serving the scientific community by providing proven, trusted, and state-of-the-art DNA and RNA research technologies at affordable prices. The company’s philosophy is to provide the highest quality products in the industry while ensuring they are both simple to use and robust in their performance. Although historically recognized for its innovative DNA and RNA purification technologies, Zymo Research has recently received much attention for its rapidly expanding epigenetics portfolio of products. Branding itself “The Epigenetics Company”, it is Zymo Research’s objective to develop and provide the most comprehensive set of research tools for DNA methylation analysis and epigenetics research available today.

About BASECLEAR BaseClear B.V., a private company based in Leiden, The Netherlands, was founded in 1993 as a service laboratory dedicated to deliver high quality DNA based services to researchers in the life sciences. At date the company offers a broad range of services ranging from single read DNA sequencing, Whole genome sequencing using NextGeneration platforms, synthetic DNA biology and services for forensics and quality control purposes and a whole package of supporting technologies. BaseClear strives to deliver services at an exceptional high quality level and with a strong focus on customer satisfaction, which is guaranteed through our ISO 17025 quality system and further through Illumina CSpro and Nimblegen CSpro certifications. ‘BaseClear, for 100% DNA results.’ For more information, contact: services@zymoresearch.com www.zymoresearch.com