Collect And Preserve RNA At Ambient Temperature For Viral Testing

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Protect DNA & RNA

in biological samples. No cold chain.

Inactivate Viruses

and other pathogents (bacteria, eukaryotes)

Universally Compatible

with Zymo Research, Qiagen, Roche, Thermo Fisher, etc.

DNA & RNA Protected At Ambient Temperature For >30 Days

Amient Temperature Icon for Swabs

Swabs

Amient Temperature Icon for Sputum & Saliva

Sputum & Saliva

Amient Temperature Icon for Feces

Feces

Amient Temperature Icon for Virus & Microbe Samples

Virus & Microbe Samples

Amient Temperature Icon for Tissue & Cells

Tissue & Cells

Amient Temperature Icon for Blood & Biological Fluids

Blood & Biological Fluids

Ambient temperature for DNA/RNA Preservation graph
No Freezers

Icon of a freezer

No Dry Ice

Icon of dry ice

No Cold Chain

Icon of a cold delivery truck

DNA/RNA Shield Inactivates Tough Microbes And Viruses

Image of a shield showing certifications in the middle

Used by research groups:

Viruses
Coronavirus1-3
MERS-Coronavirus4
Parvovirus5
Ebolavirus6
Dengue virus7
Chikungunya virus7-8
HSV-19-10
HSV-29-10
Influenza A1-3,11-12
Rhinovirus1-3
West Nile virus13-15
Bacteria
E. faecalis16
L. monocytogenes16
M. tuberculosis16
P. aeruginosa16
S. enterica16
S. aureus16
E. coli16
Eukaryotes
C. albicans16
C. neoformans16
S. cerevisiae16
P. malariae17

DNA/RNA Shield has been rigorously tested to ensure inactivation of the toughest viruses, such as parvovirus (5), and fulfills EN14476:2017. DNA/RNA Shield abides by the Center for Disease Control's guidelines for pathogen inactivation (18).

Well Cited For Virus And Pathogen Collection

including coronaviruses

Journal of Virology
Journal of Infectious Diseases
Journal of Virological Methods

Universal Compatibility With DNA/RNA Extraction Kits

List of companies that DNA/RNA Shield is compatible with

Reduce Preparation Steps. Automation-ready.

no additional inactivation with AVL, TRIzol, or similar

Simply transfer and load platform

Samples collected in DNA/RNA Shield can be input into existing nucleic acid extraction workflows on leading automated platforms (Tecan, Hamilton, Thermo KingFisher, and more) for high-throughput sample processing.

Commercial Testing Labs Using DNA/RNA Shield

For Remote Sampling and Safe Room Temperature Transport

List of testing labs

Top Researchers & Institutions Rely On DNA/RNA Shield

List of Groups who use the DNA/RNA Shield product.

DNA/RNA Shield In Action

Tracking MERS-CoV Transmission in the Desert

In order to survey dromedary camels in the Oman desert for Middle East respiratory syndrome coronavirus (MERS-CoV), researchers at the VetMed University in Vienna needed highly sophisticated, safe sample storage technology. DNA/RNA Shield enabled researchers to store samples in the most extreme desert temperatures while providing complete viral inactivation for safe international travel. The samples collected and stored with DNA/RNA Shield revealed the presence of MERS-CoV in several camels that are closely related to human MERS-CoV, suggesting possible transmission of MERS-CoV from camel to human.

NASA-Validated Sample Preservation in Space

NASA Researchers needed the best sample storage, preservation and biohazard inactivation technology available for groundbreaking research on the International Space Station (ISS). As the only product that can maintain a biostatic 'genetic snapshot' of collected samples while inactivating any biohazardous material, DNA/RNA Shield was the clear choice for future missions. DNA/RNA Shield's unparalleled sample storage and preservation technology allows NASA to reach new limits and study the effects of microgravity of the human microbiome.

Collection and Inactivation of Malaria in Remote Areas

A malariologist from the University of Maryland School of Medicine (UMD) aimed to assess one of the biggest challenges in eradicating malaria from the Mekong region of Southeast Asia - identifying asymptomatic carriers of the disease. Traditional sample collection, storage, and preservation devices did not have the portability required for the infectious parasitic disease research in inaccessible regions; nor did they allow detection of low parasitic loads. DNA/RNA Shield enabled researchers to safely work in the field and travel internationally while preserving low levels of parasite DNA.

DNA/RNA Shield Formats

Organizations in need of assistance regarding products and services for COVID-19 should inquire here:

or call (888) 882-9682

The FDA EUA Authorized end-to-end workflow - Quick SARS-CoV-2 rRT PCR Kit, includes Zymo Research's innovative technologies below:
Sample Collection
Sample Prep
Real-Time PCR
Sample Collection
Shield Swab and Saliva Collection

DNA/RNA Shield™ devices used for the collection of upper and lower respiratory specimen and transport at ambient temperature.

(no cold-chain needed)

Sample Prep
Direct-zol RNA Microprep Kits

Quick-DNA/RNA Viral MagBead used for both manual and automated processing of clinical specimen.

Real-Time PCR
Quick SARS-CoV-2 Kit

Quick SARS-CoV-2 rRT-PCR kit used for high sensitivity detection of SARS-CoV-2

Intended use of the products mentioned in the graphic above may vary. For specific intended use statements please refer to the instructions for use.

Authorized laboratories using the Quick SARS-CoV-2 rRT-PCR Kit must run the assay as outlined in the Instructions for Use. Deviations from the FDA authorized procedures, including the authorized instruments, authorized extraction methods, authorized clinical specimen types, authorized control materials, authorized other ancillary reagents and authorized materials required to perform the Quick SARS-CoV-2 rRT-PCR Kit are not permitted.

References
  1. Birger, R, et al. "Asymptomatic shedding of respiratory virus among an ambulatory population across seasons." mSphere 3(4) (2018).
  2. Galanti, Marta, et al., "Longitudinal active sampling for respiratory viral infections across age groups" Influenza and Other Respiratory Viruses, 13(3) (2019).
  3. Shaman, J, et al., "Asymptomatic summertime shedding of respiratory viruses" The Journal of infectious
  4. Nowotny, N, and Kolodziejek, J, “Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels, Oman, 2013” Eurosurveillance, 19(16) (2014).
  5. Eurovir, Virucidal activity if the nucleic acid preservation product “DNA/RNA Shield” against the murine parvovirus (MVM) at 20°C
  6. Ebolavirus - Validated by L. Avena and Dr. A. Griffiths, Department of Virology and Immunology, Texas Biomedical Research Institute.
  7. Phommanivong, V, et al. ”Co-circulation of the dengue with chikungunya virus during the 2013 outbreak in the southern part of Lao PDR” Tropical Medicine and Health, 44(24) (2016).
  8. Carrau, L, et al., "Chikungunya virus vaccine candidates with decreased mutational robustness are attenuated in vivo and have compromised transmissibility." Journal of Virology, 93(18) (2019).
  9. Gardner JK, et al. “IL-36γ Is a Key Regulator of Neutrophil Infiltration in the Vaginal Microenvironment and Limits Neuroinvasion in Genital HSV-2 Infection" The Journal of Immunology (2019).
  10. HSV-1/2 - Validated by H. Oh, F. Diaz and Prof. D. Knipe, Virology Program, Harvard Medical School.
  11. Dornfeld, D, et al., "SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses" Scientific Reports, 8(1) (2018).
  12. Influenza A - Validated by D. Poole and Prof. A. Mehle, Department of Medical Microbiology and Immunology, University of Wisconsin, Madison.
  13. Ronca, SE, et al. ,"Phenotypic and Genotypic Characterization of West Nile Virus Isolate 2004Hou3" International Journal of Molecular Sciences, 20(8) (2019).
  14. Hepp, CM, et al., "Phylogenetic analysis of West Nile Virus in Maricopa County, Arizona: Evidence for dynamic behavior of strains in two major lineages in the American Southwest." PloS ONE, 13(11) (2018).
  15. Kolodziejek J, et al., “West Nile Virus Positive Blood Donation and Subsequent Entomological Investigation, Austria, 2014” PLoS ONE, 10(5) (2015).
  16. Bacteria and Yeast - Validated by Zymo Research Corporation.
  17. Elbadry MA, et al., “High prevalence of asymptomatic malaria infections: a cross-sectional study in rural areas in six departments in Haiti” Malaria Journal, 14:510 (2015).
  18. CDC, Guidance on the inactivation or removal of select agents and toxins for future use.