Biological Research Services

Species analyzed by Zymo Research biological research services

Available Biological Research Services

Biological research services are customizable and can
be combined to suit your needs!

or contact us at
Tel: (949) 679-1190
Toll-Free: (888) 882-9682

Biological Research Services Made Simple

Just send us your samples, and we will return the genome-wide analyses as customizable publication-ready graphs and figures!

Zymo Research makes genome-wide epigenetic analyses available to every researcher with its comprehensive repertoire of biological research services. All Next-Gen epigenetic sequencing services feature state-of-the-art sample prep technologies and workflows, cutting-edge bioinformatics, and are offered at competitive pricing. With our services, you don't have to be a bioinformatics guru; instead, our bioinformatics specialists will send you the data as a comprehensive report that is publication-ready and can be customized to fit your needs. Since we develop most of the technologies used for our biological research services, our scientists and bioinformatics specialists are always available to answer your questions and assist you every step of the way.

Following the publication of the sequence of the human genome in 2001, and more recently the ENCODE Project in 2012, it has become clear that genes and chromatin are far more complicated than previously appreciated. DNA once believed to be "junk" has been found to code for specific non-coding transcripts and to contain important regulatory elements. It is now apparent that investigating one or a few genes, or only performing one type of analysis, is no longer sufficient to answer the questions currently posed by researchers in the fields of molecular biology, genetics, and systems biology. The genome-wide services offered by Zymo Research can be combined, allowing you to analyze DNA methylation and histone methylation, for example, giving you the opportunity to "Catch More" data from each sample.

The scientists at Zymo Research have been developing industry leading epigenetic technologies and workflows for over a decade, and they remain committed to pioneering new research tools and biological research services to meet the future challenges of the rapidly growing field of epigenetics.

Services for Accurate Research Outcomes

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Genome-Wide DNA Methylation Analysis

Next-generation bisulfite sequencing platforms for DNA methylation analysis. Applicable to a broad range of sample sources (human, mouse, rat, plant, etc.) and compatible with low DNA input. Streamlined workflows with comprehensive bioinformatic analysis and high quality publishable data delivery. This biological research service can be customized and combined with rapid turnaround at an affordable cost.

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Targeted Bisulfite Sequencing

We make epigenetic biomarker validation simple with our MethylCheck platform. Whether you have methylation array (27K/450K/850K) data that you would like to validate in a large sample cohort or a specific gene region in mind, our scientists are available to design, validate, and evaluate site-specific DNA methylation changes. The biological research service includes: Primer Design and Validation, Targeted Amplification, Adapterization and Barcoding, Sequencing with Illumina™ Technology, Sequence Alignment to Reference Genome, DNA Methylation Analysis.

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ChIP-Seq Analysis

ChIP-­Seq is a powerful tool for genome­wide mapping of histone modifications, protein­DNA interactions, and identifying consensus proteinbinding sites in DNA. With the ChIP­Seq service, you can either perform the ChIP assay yourself and send us the enriched DNA for library construction and Next­Gen sequencing, or we can process your samples using our optimized, proprietary chromatin shearing and enrichment procedures. Included in this biological research service, we also perform the bioinformatics and statistical analyses, and send you the results in publication­ready format.

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ATAC-Seq Analysis

ATAC-seq stands for Assay for Transposase-Accessible Chromatin with high-throughput sequencing, which is a convenient method to gather genomic information. Specifically, ATAC-seq maps regions of the genome that have open chromatin, that is, regions not occupied by nucleosomes or transcription factors. Open chromatin regions can be linked to epigenetic gene regulation, making ATAC-seq a valuable tool for multiple research fields. ATAC-seq biological research services have been used in multiple fields of scientific research like immunology, neurobiology, cardiovascular diseases, single-cell chromatin accessibility studies, and others.

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RNA-Seq Analysis

RNA-Seq analysis is used for total RNA sequencing and small RNA sequencing, complete with publication-ready report and data analysis. Efficient small RNA capture and isolation including but not limited to miRNA, piwiRNA, snoRNA, etc. Service is compatible with cfRNA from plasma and serum samples. Most importantly, this biological research service includes comprehensive publication-ready small RNA expression data analysis.

Epigentic Aging Clock
Biological Age Epigenetic Clock

DNAge Epigenetic Aging Clock is based on Steve Horvath’s aging clock and utilizes SWARM™ (Simplified Whole-panel Amplification Reaction Method) technology to analyze DNA methylation patterns of >500 loci and provide epigenetic age predictions in a high throughput manner. Epigenetic modifications found in our biological research services refer to heritable changes, which play crucial biological roles independent of genetic changes. DNA methylation, one of the most studied epigenetic modifications, is now recognized as a reliable indicator of biological age and reflects diseases status.

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Microbiome Analysis

Microbiome analysis is a complete solution for unbiased microbiome profiling. The biological research service features quick turnaround as little as 2 weeks with species-level resolution with 16S sequencing. All of our microbiome analysis includes comprehensive bioinformatics and statistical analyses as well as group comparisons, presented in a user-friendly and interactive report.

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16S/ITS Targeted Sequencing

Full service includes unbiased DNA extraction (optional), library preparation, post-library QC, sequencing using the Illumina MiSeq® platform (2x300bp), and bioinformatics analysis. Bioinformatics analysis is performed using an upgraded pipeline with an in-house curated database to resolve most microbes to the species level and provide increased coverage of organisms. The final report includes publication-ready compositional bar plots, taxonomy heat maps, alpha-diversity plots, beta-diversity plots, LEfSe biomarker discovery, and Taxa2SV decomposer analysis.

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COVID-19 Variant Sequencing

COVID-19 variant sequencing is used to ientify and track variant strains of SARS-CoV-2. Included in this biological research service are viral transport devices. This facilitates safe and stable transport of SARS-CoV-2 positive samples (from testing labs, collection sites, etc.) for sequencing using Illumina’s latest technology. Furthermore, all sample types can be accommodated.

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SARS-CoV-2 Wastewater Monitoring

Wastewater testing for SARS-CoV-2 currently allows the earliest detection of COVID-19 cases and variants possible. Our wastewater COVID-19 monitoring service can detect cases and variants up to 7 days before symptoms in the community appear. This affords more time to allocate vaccine resources, implement policies and adequately prepare hospitals.

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