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DNA/RNA Shield
Highlights
- Protect DNA and RNA in any biological sample without cold chain
- Pathogen inactivation (bacteria, virus, eukaryotic)
- Streamlined purification – universally compatible and automatable

Original Manufacturer
Innovated in California, Made in the USA
Satisfaction 100% guaranteed, read Our Promise
DNA/RNA Shield
Highlights
- Protect DNA and RNA in any biological sample without cold chain
- Pathogen inactivation (bacteria, virus, eukaryotic)
- Streamlined purification – universally compatible and automatable

Original Manufacturer
Innovated in California, Made in the USA
Satisfaction 100% guaranteed, read Our Promise
Cat # | Name | Size | Price | Quantity |
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R1100-50 | DNA/RNA Shield | 50 ml | $72.10 |
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R1100-250 | DNA/RNA Shield | 250 ml | $255.60 |
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R1200-25 | DNA/RNA Shield (2X Concentrate) | 25 ml | $72.10 |
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R1200-125 | DNA/RNA Shield (2X Concentrate) | 125 ml | $255.60 |
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Description
Performance
Technical Specifications
Applicable For | Next-Generation Sequencing, qPCR, microarray |
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Format | Reagent |
Shelf Life | 60 months at ambient temperature |
Sample Source | Cells, tissues, blood, plasma, serum, saliva, urine, feces, environmental samples, etc. |
Sample Stability | RNA: Ambient temperature (4°C- 30°C) at least 1 month DNA: Ambient temperature (4°C- 30°C) at least 24 months DNA & RNA: Frozen (< -20°C): Indefinitely |
Resources
FAQ
This can happen on occasion due to transport or storage at lower temperatures. The reagent functionality is not affected; however, the precipitate can be resolved by heating the reagent to >37 °C.
No, tissues do not need to be homogenized.
Transfer tissues in to DNA RNA Shield at room temperature, submerge. Tissue can be homogenized or stored frozen prior to homogenization.
Yes, sort directly into DNA/RNA Shield (e.g. Collect 100 µl of FACS sorted cells into minimally 400 µl of DNA/RNA Shield).
DNA & RNA (<-20°C): Indefinitely
RNA > 1 month DNA > 2 years
DNA/RNA Shield can be used on a wide variety of sample types including cells, tissues, biological fluids (plasma, serum, saliva, urine), and environmental samples (feces, plants, swabs, etc.).
Yes, extracted nucleic acids are stabilized in DNA/RNA Shield. Prior to downstream applications, clean-up the sample via the appropriate Zymo Research clean-up kit (Genomic DNA Clean and Concentrator (gDCC), DNA Clean and Concentrator (DCC), and RNA Clean and Concentrator (RCC)).
Avoid mixing the reagent and bleach (sodium hypochlorite) or other strong oxidizing agents and acids. Clean up any accidental spills with water first.
Reviews
"I did an assay using RNA/DNA shield and it works perfect. The product has excellent reproducibility when stored at 4°C for up to a month."
Maha AE.
University of Florida
"I’m a Zymo fan! DNA/RNA Shield is a great product. It works great on my precious samples. I trust Zymo Research products and they have great tech support!!"
Laura T.
USDA
"We use DNA/RNA shield and it works well with adults mosquitoes, larvae, eggs. We store it at RT for weeks and at -4 or -20 for months, never saw any DNA degradation."
Umberto P.
University of Pavia