Unbiased Results
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Nucleic Acid Preservation Without Cold Chain
DNA/RNA Shield™ stabilizes nucleic acids in samples at ambient temperature, eliminating the need for wet or dry ice during transport. DNA and RNA is protected from degradation, ensuring high-quality samples for NGS and (RT)qPCR.
Tissue Stability
RNA transcripts remain stable during extended ambient storage. (RT)qPCR analysis shows no detectable degradation of multiple RNA targets from mouse tissue stored in DNA/RNA Shield™ after 28 days at room temperature. RNA was extracted using the Quick-RNA™ Miniprep Plus kit.
Cell Stability
Total RNA including small RNA remain intact over 28-day period. Cultured mammalian cells stored in DNA/RNA Shield™ at ambient temperature and extracted using the Quick-RNA™ Miniprep kit. Total RNA was visualized via gel electrophoresis.
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Microbiome Preservation for Metagenomics and Metatranscriptomics
Capture a precise genetic snapshot of the microbial community at time of collection. DNA and RNA in any sample type are immediately stabilized to prevent degradation providing high-quality input for next-generation sequencing applications.
DNA Profiling
RNA Profiling
Microbial composition of collected stool samples remain unchanged after one month at ambient temperature with DNA/RNA Shield™. DNA and RNA were extracted using the ZymoBIOMICS DNA/RNA Miniprep Kit and were subjected to microbial composition DNA and RNA profile sequencing.
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Protection for Both Transport and Storage
In addition to ambient temperature stability, protect against the effects of freeze-thaw cycling. Storing samples in DNA/RNA Shield™ maintains RNA integrity and consistency throughout storage and handling.
Whole Blood RNA stability
RNA targets from human whole blood remain intact >1 month. Human whole blood was drawn into DNA/RNA Shield™ Blood Collection tubes and total RNA was extracted using the Quick-RNA™ Whole Blood Miniprep kit and analyzed via (RT)qPCR.
Freeze-thaw Protection
Total RNA is protected from degradation after freeze-thaw cycling. Human whole blood stored in DNA/RNA Shield™ compared to EDTA (not protected) was frozen at -20C and thawed to room temperature. Total RNA from whole blood was extracted using Quick-RNA™ Whole Blood Miniprep kit.
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Stabilize Pathogen Nucleic Acid At Time of Collection
Ensure reliable, long-term DNA & RNA preservation to support accurate infectious disease surveillance and longitudinal studies (viral, bacterial, eukaryotic).
SARS-CoV-2 RNA Stability in DNA/RNA Shield
Swab samples collected in DNA/RNA Shield™ keeps SARS-CoV-2 viral RNA stable for >28 days at room temperature. Samples were processed using the Quick-DNA/RNA Viral Magbead kit and analyzed via rRT-PCR
510(k)-Cleared FDA Class II Medical Device (FDA Summary)
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Collect Saliva for Host and Microbial Analysis
Preserve host and microbial (virus, bacteria, and yeast) DNA/RNA directly from saliva. Perfect for safeguarding saliva during transport and storage, enabling reproducible results for pathogen detection, microbiome profiling, and genomic analysis.
Unmatched Saliva DNA & RNA stability
Saliva DNA & RNA remain stable over a month-long period. (RT)qPCR analysis shows no detectable degradation of DNA & RNA (HSV & HIV-I) from human saliva stored in DNA/RNA Shield™ after 30 days at room temperature. DNA & RNA from was extracted using the Quick-RNA™ Viral kit.
40% more miRNAs detected
Superior miRNA recovery for downstream sequencing. miRNA from samples collected in DNA/RNA Shield™ was extracted with the Quick-RNA™ Miniprep Plus kit. The extracted RNA was used for miRNA-seq, resulting in improved sensitivity and data quality.
* 59 low frequency miRNA (only being picked up once). Sequencing error in either sample could partially contribute to it. However, a lot of the miRNAs only detected in DNA/RNA Shield samples had multiple counts but were still missed in PAXgene samples. Disclaimer: PAXgene is a registered trademark of PreAnalytiX, Gmbh
Trusted Sample Preservation in Extreme Conditions
Mission to Mars
International Space StationTherapeautic Discovery
Channel Islands, CaliforniaSARS-CoV2 Sequencing
Quito, EcuadorGlacial Microbiome
Snaefellsjökull and Langjökull, IcelandMalaria Elimination
Myanmar, Greater Mekong SubregionMERS-CoV Surveillance
Oman DesertLion Conservation
Kruger National Park, South AfricaKoala Rehabiliation
New South Wales, AustraliaSeabird Ecology
Antarctic Peninsula
Mission to Mars
Optimizing Astronaut Diets for Missions to Mars
For research aboard the International Space Station, NASA turned to DNA/RNA Shield™ to preserve and inactivate biological samples safely. Its unique ability to maintain a stable genetic snapshot while neutralizing biohazards made it the only choice for studying the human microbiome in microgravity—pushing the boundaries of science beyond Earth.
Malaria Elimination
Collection and Inactivation of Malaria in Remote Areas
A malariologist from the University of Maryland School of Medicine (UMD) aimed to assess one of the biggest challenges in eradicating malaria from the Mekong region of Southeast Asia - identifying asymptomatic carriers of the disease. Traditional sample collection, storage, and preservation devices did not have the portability required for the infectious parasitic disease research in inaccessible regions; nor did they allow detection of low parasitic loads. DNA/RNA Shield™ enabled researchers to safely work in the field and travel internationally while preserving low levels of parasite DNA.
MERS-Cov Surveillance
Tracking MERS-CoV Transmission in the Desert
In order to survey dromedary camels in the Oman desert for Middle East respiratory syndrome coronavirus (MERS-CoV), researchers at the VetMed University in Vienna needed highly sophisticated, safe sample storage technology. DNA/RNA Shield™ enabled researchers to store samples in the most extreme desert temperatures while providing complete viral inactivation for safe international travel. The samples collected and stored with DNA/RNA Shield™revealed the presence of MERS-CoV in several camels that are closely related to human MERS-CoV, suggesting possible transmission of MERS-CoV from camel to human.
SARS-CoV2 Sequencing
Withstanding Extreme Conditions in Real-World Emergency
In a remarkable real-world test of resilience, researchers in Ecuador experienced a transportation emergency when a vehicle carrying clinical specimens caught fire, exposing the shipment to extreme heat. Despite the intense conditions—burned packaging and prolonged exposure—samples preserved in DNA/RNA Shield™ remained intact for RNA-seq. Upon arrival, the team successfully sequenced SARS-CoV-2 genomes, demonstrating the exceptional stability and reliability of DNA/RNA Shield™ for preserving genetic material even under catastrophic circumstances.
Koala Rehabiliation
Koala-ty Control: Cleaning Up Care Spaces
Researchers investigated how Chlamydia pecorum—a serious bacterial threat to koala health—can persist in rehabilitation settings where animals share space and equipment. Researchers swabbed surfaces before and after cleaning at a care facility in New South Wales, using DNA/RNA Shield™ to preserve the samples for accurate detection. While chlamydial DNA was commonly found, especially on surfaces with direct koala contact, only a few samples contained live bacteria. These findings highlight the need for better disinfection protocols and the critical role of biosecurity surveillance.
Lion Conservation
Shaping the Future of Lion Conservation
Researchers in South Africa are investigating how tuberculosis (TB) and gut microbiome changes impact the health of African lions, a species at risk due to habitat loss, disease, and environmental pressures. During fieldwork in Kruger National Park, scientists used DNA/RNA Shield™ Fecal Collection Tubes and DNA/RNA Shield™ blood tubes to safely preserve lion feces and blood respectively, without refrigeration and ensuring pathogen inactivation and intact genetic integrity. This preservation was critical for accurately studying the role of TB in lion health and supports ongoing efforts to protect these iconic predators and maintain ecosystem balance.
Glacial Microbiome
Glacial Microbes, Preserved with Confidence
Preserving nucleic acids for sequencing in remote, low-biomass environments like glaciers presents significant challenges for field researchers. In a comparative study of microbial communities from Icelandic snow and ice, three preservation methods—flash freezing, RNAlater, and Zymo DNA/RNA Shield™—were evaluated. While all methods performed similarly for DNA in high-biomass samples, Zymo DNA/RNA Shield™ stood out for its superior RNA preservation, especially when compared to RNAlater. Crucially, it offers a practical, high-yield alternative to liquid nitrogen, making it an ideal solution for fieldwork in logistically demanding environments where maintaining sample integrity without cold storage is essential.
Seabird Ecology
Enabling Breakthroughs in Avian Ecology
Scientists are reshaping how we understand and protect avian populations. Braving harsh conditions—including seasickness and the extreme environment of the Antarctic Peninsula—scientists use DNA/RNA Shield™ to preserve fecal samples from seabirds like puffins, terns, and penguins. This powerful preservation technology enables high-throughput DNA extraction and metabarcoding, allowing researchers to accurately analyze diets and monitor biodiversity without sample degradation. Her research provides critical insights into predator-prey interactions and informs sustainable ocean management strategies, with the goal of restoring marine ecosystems to a healthy, balanced state that supports diverse seabird and marine mammal populations.
Therapeautic Discovery
Toxic Algae Therapeutics for Marine Mammals
Scientists launched a vital research collaboration to combat the rising threat of domoic acid (DA) poisoning in marine mammals, especially sea lions. Triggered by climate change and increasingly frequent harmful algal blooms, DA toxicity causes severe neurological and cardiac symptoms in marine life and poses a health risk to humans. With no current treatment available, the initiative preserved samples from affected animals using DNA/RNA Shield™ in the field, conduct RNA sequencing, and analyze gene expression data through Unravel’s AI-driven BioNAV™ platform to identify promising therapeutic candidates. This groundbreaking collaboration not only aims to develop the first effective treatments for DA poisoning but also highlights the broader environmental and public health implications of oceanic toxin exposure.
Complete Pathogen Inactivation
Virus
- West Nile Virus
- Monkeypox Virus
- Murines Parvovirus
- Dengue Virus
- Ebolavirus
- SARS-CoV-2
- Herpes Simplex Virus-1
- Herpes Simplex Virus-2
- HIV-1
- Influenza A (H1N1)
- Avian bird Flu (H5N1)
- Influenza A (H7N7)
- Rabies (Tollwut) Virus
- MERS-Coronavirus
- Chikugunya Virus
- Rhinovirus
- Aphthovirus virus (FMD)
- Zika Virus
- Norovirus
- Enterovirus
- Adenovirus
- RSV
Bacteria & Archaea
- Mycobacterium tuberculosis
- Staphylococcus aureus
- Enterococcus hirae
- Pseudomonas aeruginosa
- Escherichia coli K12
- Faecalibacterium prausnitzii
- Veillonella rogosae
- Roseburia hominis
- Bacteroides fragilis
- Prevotella corporis
- Bifidobacterium adolescentis
- Fusobacterium nucleatum
- Lactobacillus fermentum
- Clostridioides difficile
- Akkermansia muciniphila
- Methanobrevibacter smithii
- Salmonella enterica
- Enterococcus faecalis
- Clostridium perfringens
- Escherichia coli
- Xylella fastidosa
Yeast & Eukaryotes
- Saccharomyces cerevisiae
- Candida albicans
- Cryptococcus neoformans
- Plasmodium Malaria
- Babesia spp.
- Cryptosporidium spp.
- Aspergillus spp.
- Giardia lamblia
- Toxoplasma gondii
Direct Compatibility On Automated Platforms
Streamlined Purification of DNA & RNA
- No reagent removal
- Fully automatable
- Compatible with most purification kits
FDA EUA & CE IVD Certified
The DNA/RNA Shield product line contains sample storage devices for clinical diagnostic applications that are FDA 510(k) cleared, Emergency Use Authorized and CE-marked
Top Researchers & Institutions Rely On DNA/RNA Shield
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