Direct-zol-96 MagBead RNA

R2100 / R2101 / R2102 / R2103 / R2104 / R2105

Direct-zol-96 MagBead RNA

R2100 / R2101 / R2102 / R2103 / R2104 / R2105

Cat # Name Size Price Quantity
R2100 Direct-zol-96 MagBead RNA 2 x 96 preps $422.00
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R2101 Direct-zol-96 MagBead RNA (Product Supplied w/ 200 ml TRI Reagent) 2 x 96 preps $635.00
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R2102 Direct-zol-96 MagBead RNA 4 x 96 preps $684.00
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R2103 Direct-zol-96 MagBead RNA (Product Supplied w/ 200 ml x 2 TRI Reagent) 4 x 96 preps $1,102.00
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R2104 Direct-zol-96 MagBead RNA 8 x 96 preps $1,085.00
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R2105 Direct-zol-96 MagBead RNA (Product Supplied w/ 200 ml x 4 TRI Reagent) 8 x 96 preps $1,915.00
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Isolate total RNA and small/miRNA from TRIzol without phase separation


  • Easy Handling: Bypass chloroform, phase separation and precipitation steps.
  • NGS-Ready: Ultra-pure RNA without phenol carryover. No DNA contamination (DNase I included).
  • Non-Biased: Complete RNA recovery without miRNA loss.


The Direct-zol™-96 MagBead RNA kit provides a high-throughput (96-well), magnetic bead-based isolation of high-quality RNA directly from samples in TRI Reagent® and similar. The extraction method inactivates viruses and other infectious agents. Total RNA including small/microRNAs (≥17 nt) are effectively isolated from a variety of sample sources (cells, tissues, biological liquids, etc.). The procedure is easy: simply add ethanol and MagBinding Beads to a sample in TRI Reagent®, wash and elute the RNA. No phase separation, precipitation, or post-purification steps are necessary. The result is broad range purification of small and large RNAs suitable for subsequent RNA-based methods including Next-Gen sequencing, RT-PCR, transcription profiling, hybridization, etc.

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Technical Specifications

Compatibility TRIzol®, RNAzol®, QIAzol®, TriPure™, TriSure™ and all other acid-guanidinium-phenol based solutions can be used in place of TRI Reagent®.
Equipment Microcentrifuge, vortex, magstand
Sample Inactivation TRI Reagent® (provided with R2101, R2103, and R2105) inhibits RNase activity and inactivates viruses and other infectious agents.
Sample Source Any sample stored and preserved in TRI Reagent®, TRIzol® or similar (animal cells, tissue, bacteria, yeast, fecal, biological fluids, and in vitro processed RNA (e.g., transcription products, DNase-treated or labeled RNA)).
Size Range Total RNA ≥ 17 nt
Yield 10 µg RNA (binding capacity), ≥ 30 µl (elution volume)

Product FAQ

Q1: Is Direct-zol suitable for very small numbers of cells?

Q2: Is DNase I available for individual purchase?

Q3: How to store DNase-I following resuspension?

Q4: Is the DNase-I treatment necessary?

Q5: Is the kit compatible with samples stored in DNA/RNA Shield?

Q6: Is it possible to extract proteins with the Direct-zol RNA kits?

Q7: Can samples be stored in TRIzol/TRI Reagent prior to processing?

Q8: Is it possible to isolate DNA with the Direct-zol RNA kits?

Q9: Is the RNA suitable for Next-Gen sequencing or other sensitive downstream applications?

Q10: Which phenol-based reagents are compatible with Direct-zol?

Q11: What is the difference between the Direct-zol RNA and Quick-RNA kits?

Q12: What is the difference between the Direct-zol RNA MiniPrep and the Direct-zol RNA MiniPrep Plus?

Q13: I ran out of RNA Wash Buffer. Can I use something else?

Product Video



“Before I discovered this kit, I was isolating RNA the old school way with chloroform and it would take half the day to finish the protocol. The Direct-zol RNA Miniprep kit is AWESOME! It took hardly any time, the protocol was so easy, and my RNA quality was SO much better. Honestly, this kit revolutionized my life at the bench.”

- A. Newhart (The Wistar Institute)

“Simple protocol and yielded good quality of RNA. Only one kit working for all type of tissue, cell and especially biological fluids.”

- Mohan K. (University of Illinois, Chicago)

“Previously I used a protocol that took 3 hours, now I can have my RNA in 20 minutes. What is not to like about that? Just one column and two buffers, I love it.”

- Arjan V. (Indiana University)

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Kit Components