Breakthrough. Superior nucleic acid preservation and purification for any sample.

How We Can Help You Break Through

Overcome Challenging Sample Types

Proprietary lysis and purification solutions provide unbiased nucleic acid extraction at high concentrations from even the most difficult sample types.

Streamlined Sample Prep Workflows

Advanced nucleic acid purification technology enables rapid recovery of DNA and/or RNA that is ideal for low and high-throughput applications as well as automation.

Achieve NGS Ready DNA & RNA

Extensive publication track record of proven compatibility with all major sequencing platforms – Illumina, PacBio, Oxford Nanopore, etc.

Enabling Breakthroughs in...

Cancer Immunotherapy

Traditional cancer treatments, like chemotherapy, are non-specific, attacking healthy tissue as well as cancer cells which causes extreme side effects. Cancer immunotherapy overcomes this problem by utilizing the patient's own immune system to specifically target only cancer cells. Scientists set out to develop a more powerful immunotherapy by creating a genetically engineered multifunctional exosome that both guides and stimulates T cells towards killing cancer cells. To generate the exosomes, transfection-grade plasmid vectors encoding the exosome were purified using ZymoPURE II Plasmid Kits and then transfected into a human cell line. These genetically engineered multifunctional exosomes successfully targeted cancer cells and inhibited tumor growth in a mouse model for triple-negative breast cancer more effectively than exosomes that only guided or stimulated T cells. Read more on this study.
Pathogen Surveillance

Rabies is a fatal viral disease that accounts for ~60,000 human deaths annually, making detection and epidemiological tracking critical to prevention. Conventional post-mortem rabies testing requires highly skilled technicians and can only be performed with fresh tissue. To help make rabies testing more accessible, researchers developed a simple rabies assay that utilizes RT-PCR to amplify and identify a conserved genomic region of the rabies virus, even in deteriorated or fixed tissue. Viral RNA from brain stem samples originating from rabies-suspected animals spanning across the globe were extracted using the Direct-zol RNA Miniprep Kit to ensure high quality RNA was recovered from the lipid-rich tissue and used for the assay. The assay enabled successful detection of the rabies virus even in samples unsuitable for traditional testing. Learn more about this research.
Water Conservation

Water conservation is a growing concern with increasing pressure to reduce stress on groundwater resources. The world's largest potable water reuse facility, which recharges municipal groundwater with 100 million gallons of water per day, performed metagenomic sequencing to assess the effectiveness of their wastewater treatment system. All wastewater samples were stored in DNA/RNA Shield to preserve the nucleic acids at ambient temperatures and the ZymoBIOMICS DNA/RNA Miniprep Kit was used for nucleic acid extractions to ensure downstream microbial profiling was unbiased and accurate. With these solutions, researchers were able to detect potential human pathogens and verify that their treatment was effective in transforming wastewater into potable water. Learn more on this study.
Cell Therapy

Ischemic stroke accounts for 87% of all strokes, but existing treatments must be administered immediately to be effective and are unable to repair any tissue damage caused by stroke. To overcome these challenges, researchers developed a cell therapy using fibroblasts that were reprogrammed by transfecting with plasmids encoding development transcription factors known to induce intracranial vasculogenesis using a novel non-viral nanochannel-driven gene delivery system. The plasmids encoding these transcription factors were purified using the ZymoPURE II Plasmid Midiprep Kit, to ensure transfection-grade quality plasmid DNA. It was found that delivery of the reprogrammed fibroblasts into a mouse model of ischemic stroke repaired stroke damage and significantly improved locomotive skills, demonstrating the potential of this therapy for treating ischemic stroke. Read more on this research.

Enabling Breakthroughs in...

Cancer Immunotherapy

Traditional cancer treatments, like chemotherapy, are non-specific, attacking healthy tissue as well as cancer cells which causes extreme side effects. Cancer immunotherapy overcomes this problem by utilizing the patient's own immune system to specifically target only cancer cells. Scientists set out to develop a more powerful immunotherapy by creating a genetically engineered multifunctional exosome that both guides and stimulates T cells towards killing cancer cells. To generate the exosomes, transfection-grade plasmid vectors encoding the exosome were purified using ZymoPURE II Plasmid Kits and then transfected into a human cell line. These genetically engineered multifunctional exosomes successfully targeted cancer cells and inhibited tumor growth in a mouse model for triple-negative breast cancer more effectively than exosomes that only guided or stimulated T cells. Read more on this study.

Infectious Disease Diagnostics

Pathogen Surveillance

Rabies is a fatal viral disease that accounts for ~60,000 human deaths annually, making detection and epidemiological tracking critical to prevention. Conventional post-mortem rabies testing requires highly skilled technicians and can only be performed with fresh tissue. To help make rabies testing more accessible, researchers developed a simple rabies assay that utilizes RT-PCR to amplify and identify a conserved genomic region of the rabies virus, even in deteriorated or fixed tissue. Viral RNA from brain stem samples originating from rabies-suspected animals spanning across the globe were extracted using the Direct-zol RNA Miniprep Kit to ensure high quality RNA was recovered from the lipid-rich tissue and used for the assay. The assay enabled successful detection of the rabies virus even in samples unsuitable for traditional testing. Learn more about this research.

Water Conservation

Water conservation is a growing concern with increasing pressure to reduce stress on groundwater resources. The world's largest potable water reuse facility, which recharges municipal groundwater with 100 million gallons of water per day, performed metagenomic sequencing to assess the effectiveness of their wastewater treatment system. All wastewater samples were stored in DNA/RNA Shield to preserve the nucleic acids at ambient temperatures and the ZymoBIOMICS DNA/RNA Miniprep Kit was used for nucleic acid extractions to ensure downstream microbial profiling was unbiased and accurate. With these solutions, researchers were able to detect potential human pathogens and verify that their treatment was effective in transforming wastewater into potable water. Learn more on this study.

Cell Therapies

Cell Therapy

Ischemic stroke accounts for 87% of all strokes, but existing treatments must be administered immediately to be effective and are unable to repair any tissue damage caused by stroke. To overcome these challenges, researchers developed a cell therapy using fibroblasts that were reprogrammed by transfecting with plasmids encoding development transcription factors known to induce intracranial vasculogenesis using a novel non-viral nanochannel-driven gene delivery system. The plasmids encoding these transcription factors were purified using the ZymoPURE II Plasmid Midiprep Kit, to ensure transfection-grade quality plasmid DNA. It was found that delivery of the reprogrammed fibroblasts into a mouse model of ischemic stroke repaired stroke damage and significantly improved locomotive skills, demonstrating the potential of this therapy for treating ischemic stroke. Read more on this research.

Breakthrough Sample Prep Solutions

Sample Collection & Preservation

Eliminate cold chain storage and transport while maintaining safety and sample integrity.

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DNA Purification

Recover highly concentrated inhibitor-free DNA from difficult-to-lyse samples containing low DNA.

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RNA Purification

Isolate high yields of intact total RNA, including miRNA, from any sample using the fastest protocols available.

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Plasmid Purification

Purify milligrams of transfection-grade plasmid in just minutes using a simple spin-column protocol.

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Featured Technologies

Great Science Starts with Sample Collection

Eliminate cold chain storage and transport while maintaining safety and sample integrity.

DNA/RNA Shield

A stabilization solution that instantly inactivates pathogens and preserves DNA/RNA at ambient temperature, eliminating cold-chain needs during transport and ensuring reliable downstream analysis.

DNA/RNA Shield SafeCollect Saliva Collection Kit

A simple, at-home collection kit for saliva and sputum specimen preservation at ambient temperature that inactivates pathogens.

Bunny Wipe Fecal Sample Collector

At-home fecal collection device that stabilizes DNA/RNA at ambient temperatures.

Great Science Starts with Sample Collection

Eliminate cold chain storage and transport while maintaining safety and sample integrity.
Purity by Design

Recover highly concentrated inhibitor-free DNA from difficult-to-lyse samples containing low DNA.

DNA Clean & Concentrator-5

Purify up to 5 µg of highly concentrated ultra-pure DNA from PCR, enzymatic reactions, and other sources in 2 minutes.

MAGicBead™ cfDNA Isolation Kit

Unique, magnetic bead surface chemistry that facilitates unparalleled cfDNA recovery from biofluids.

ZymoBIOMICS DNA Miniprep Kit

Efficient microbial DNA purification from a variety of sample inputs for highly accurate microbiome and metagenome analyses.

Purity by Design

Recover highly concentrated inhibitor-free DNA from difficult-to-lyse samples containing low DNA.
Recover Unbiased Total RNA Purification

Isolate high yields of intact total RNA, including miRNA, from any sample using the fastest protocols available.

Direct-zol RNA Microprep Kit

Recover ultra-pure total RNA including miRNA directly from low-input samples in TRI Reagent in 7 minutes without chloroform, phase separation or tedious alcohol precipitation steps.

Quick-RNA Miniprep Kit

Extract high yields of ultra-pure total RNA, including miRNA, from any sample.

RNA Clean & Concentrator-25 Kit

Purify highly concentrated ultra-pure RNA from any enzymatic reactions (e.g., RT-PCR, DNase treatment, in vitro transcription, etc.) in 5 minutes.

Recover Unbiased Total RNA Purification

Isolate high yields of intact total RNA, including miRNA, from any sample using the fastest protocols available.
Elevating Plasmid Purification

Purify milligrams of transfection-grade plasmid in just minutes using a simple spin-column protocol.

ZymoPURE Plasmid Miniprep Kit

Rapid spin-column purification of transfection-grade plasmid DNA from up to 5 ml of E. coli culture.

ZymoPURE II Plasmid Midiprep Kit

Fastest and simplest method available to purify up to 1.2 mg of endotoxin-free plasmid DNA from up to 50 ml of E. coli culture.

ZymoPURE II Plasmid Maxiprep Kit

Fastest and simplest method available to purify up to 3 mg of endotoxin-free plasmid DNA from up to 150 ml of E. coli culture.

Elevating Plasmid Purification

Purify milligrams of transfection-grade plasmid in just minutes using a simple spin-column protocol.

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Insights to Optimize Sample Prep

Breakthrough eBooks with expert tips to overcome sample prep challenges

Download practical guides for all your workflows.

How to Reliably Isolate RNA

Isolate RNA reliably across challenging sample types from RNA degradation, low yield and/or purity, and DNA contamination.

How to Increase Plasmid Yield

Troubleshoot plasmid purification challenges and learn how to improve plasmid yields from E. coli cultures with this guide.

eBook downloads are made available only after the user submits the required contact information through the designated form. By submitting the form, the user will receive access to the applicable eBook materials and any other content requiring the same information collected through that form.

Breakthrough the Status Quo

Start with Reliable Sample Prep for Accurate Results

Consistently Recover RNA of All Sizes

High-quality, intact, small and large RNA are efficiently recovered using a Direct-zol^™ RNA kit compared to using a Supplier Q kit. RNA is DNA-free and ready for all downstream applications, including NGS.

"Excellent for most RNA, including microRNA. Efficient, easy, time saver. In my opinion, the only ...column-based RNA extraction system that efficiently recovers small RNA (including miRNA)."

Tristan Bouschet IGF

Achieve Unbiased Microbial Lysis

The ZymoBIOMICS DNA Miniprep Kit provides unbiased representation of the organisms extracted from the ZymoBIOMICS Microbial Community Standard. DNA was extracted from the ZymoBIOMICS Microbial Community Standard using four different DNA extraction methods (ZymoBIOMICS DNA Miniprep Kit, Human Microbiome Project Protocol, Supplier M, and Supplier Q) and analyzed using 16S rRNA gene sequencing.

"This kit has the most efficient lysis of all species with a very easy protocol. The unbiased lysis provides credible data and doesn't risk the most expensive downstream analysis."

Victor Yamakado Pilan UNESP